论文成果

• 1. Guo J, Zhou Y, Xu C, Chen Q, Sztupinszki Z, Börcsök J, Xu C, Ye F, Tang W, Kang J et al: Genetic Determinants of Somatic Selection of Mutational Processes in 3,566 Human Cancers. Cancer Res 2021.
• 2. Kohaar I, Li Q, Chen Y, et al. Association of germline genetic variants with TMPRSS2-ERG fusion status in prostate cancer. Oncotarget 2020; 11:1321–1333
• 3. Li W, Xu C, Guo J, et al. Cis- and Trans-Acting Expression Quantitative Trait Loci of Long Non-Coding RNA in 2,549 Cancers With Potential Clinical and Therapeutic Implications. Front. Oncol. 2020; 10
• 4.Wu J, Ge D, Zhong T, et al. IRF4 and STAT3 activities are associated with the imbalanced differentiation of T-cells in responses to inhalable particulate matters. Respir Res 2020; 21:123
• 5.Yi C, Li Q, Xiao J. Familial chilblain lupus due to a novel mutation in TREX1 associated with Aicardi-Goutie’res syndrome. Pediatr Rheumatol Online J 2020; 18:32
• 6. Zhu Y, Zhong T, Ge D, et al. Multi-Factor Analysis of Single-Center Asthma Control in Xiamen, China. Front Pediatr 2019; 7:498
• 7.Wu J, Zhong T, Zhu Y, et al. Effects of particulate matter (PM) on childhood asthma exacerbation and control in Xiamen, China. BMC Pediatr 2019; 19:194
• 8.Ott CJ, Federation AJ, Schwartz LS, et al. Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia. Cancer Cell 2018; 34:982-995.e7
• 9.Liu K, Guo J, Liu K, et al. Integrative analysis reveals distinct subtypes with therapeutic implications in KRAS-mutant lung adenocarcinoma. EBioMedicine 2018; 36:196–208
• 10.Guo J, Huang J, Zhou Y, et al. Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population. BMC Genomics 2018; 19:538
• 11.Xu S, Li Q, Wu J, et al. Identification of IL2RG and CYBB mutations in two Chinese primary immunodeficiency patients by whole-exome sequencing. Immunol Invest 2018; 47:221–228
• 12.Zhang S, Chen Q, Liu Q, et al. Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2. Cancer Cell 2017; 31:669-684.e7
• 13. Kar SP, Adler E, Tyrer J, et al. Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci. Br J Cancer 2017; 116:524–535
• 14. Zhang L, Li X, Li Q, et al. Rare RET Variant p.D707E in a Chinese Pedigree with Hereditary Medullary Thyroid Carcinoma. Pathobiology 2017; 84:152–160
• 15. Guo H, Ahmed M, Zhang F, et al. Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer. Nat Genet 2016; 48:1142–1150
• 16. Kar SP, Beesley J, Al Olama AA, et al. Genome-wide Meta-analyses of Breast, Ovarian and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by At Least Two Cancer Types. Cancer Discov 2016; 6:1052–1067
• 17. Lawrenson K, Kar S, McCue K, et al. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus. Nat Commun 2016; 7
• 18. Hong J, Zhong T, Li H, et al. Ambient air pollution, weather changes, and outpatient visits for allergic conjunctivitis: A retrospective registry study. Sci Rep 2016; 6
• 19. Fehringer G, Kraft P, Pharoah PD, et al. Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations. Cancer Res 2016; 76:5103–5114
• 20. Petrovics G, Li H, Stümpel T, et al. A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men. EBioMedicine 2015; 2:1957–1964
• 21. Spisak S, Lawrenson K, Fu Y, et al. CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants. Nat Med 2015; 21:1357–1363
• 22. Han Y, Hazelett DJ, Wiklund F, et al. Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions. Hum Mol Genet 2015; 24:5603–5618
• 23. Hoffmann TJ, Van Den Eeden SK, Sakoda LC, et al. A large multi-ethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Cancer Discov 2015; 5:878–891
• 24. Lawrenson K, Iversen ES, Tyrer J, et al. Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer. Carcinogenesis 2015; 36:1341–1353
• 25. Lawrenson K, Li Q, Kar S, et al. Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer. Nat Commun 2015; 6:8234
• 26. Kelemen LE, Lawrenson K, Tyrer J, et al. Genome-wide significant risk associations for mucinous ovarian carcinoma. Nat Genet 2015; 47:888–897
• 27. Li Q, Stram A, Chen C, et al. Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types. Hum Mol Genet 2014; 23:5294–5302
• 28. Seo J-H, Li Q, Fatima A, et al. Deconvoluting complex tissues for expression quantitative trait locus-based analyses. Philos Trans R Soc Lond B Biol Sci 2013; 368:20120363
• 29. Li Q, Seo J-H, Stranger B, et al. Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci. Cell 2013; 152:633–641
• 30. Li Q, Birkbak NJ, Gyorffy B,et al. Jetset: selecting the optimal microarray probe set to represent a gene. BMC bioinformatics 2011, 12:474.
• 31. Li Q, Eklund AC, Birkbak NJ, et al.Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response. BMC bioinformatics 2011, 12:310
• 32. Li Y, Zou L, Li Q, et al. Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. Nature medicine 2010, 16(2):214-218.